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Journal Publications

Publications: 2010-2022   (2022.08.24 updated)

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2022

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  1. Hsiang-Wei Huang, Ching-Ying Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang, Cheng-Chih Chang, and Kwang-Huei Lin CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer Oncogene 41(2):159-172. 2022. (SCI; IF: 8.756, 25/321=7.79%, Biochemistry & Molecular biology)

  2. Chia-Jung Liao, Po-Shuan Huang, Hui-Tzu Chien, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Effects of Thyroid Hormones on Lipid Metabolism Pathologies in Non-Alcoholic Fatty Liver Disease Biomedicines 10, 1232, 1-17, 2022 https://doi.org/10.3390/biomedicines10061232 (SCI; IF: 4.757,72/195=36.9%, Medicine, Research & Experimental)

  3. Pei‑Yi Chu, Wei‑Chieh Huang, Shiao‑Lin Tung, Chung‑Ying Tsai, Chih Jung Chen,Yu‑Chin Liu Chia‑Wen Lee, Yang‑Hsiang Lin, Hung‑Yu Lin, Cheng‑Yi Chen, Chau‑Ting Yeh, Kwang‑Huei Lin, and Hsiang‑Cheng Chi IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c‑MYC axis Cell & Bioscience 12:124-140, 2022 (SCI; IF: 9.606, 54/321=16.7% Biochemistry & Molecular biology)

  4. Yu-Chin Liu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Po-Shuan Huang, Chia-Jung Liao, Yu-Syuan Liou, Chiao-Chun Lin, Chia-Jung Yu, Chau-Ting Yeh, Ya-Hui Huang, and Kwang-Huei Lin CRNDE acts as an epigenetic modulator of the p300/YY1 complex to promote HCC progression and therapeutic resistance Clinical Epigenetics 14:106, 1-19. 2022 https://doi.org/10.1186/s13148-022-01326-3 (SCI; IF: 7.291, 19/175=10.9% Genetics & Heredity)

  5. Yang-Hsiang Lin, Yu-Chin Liu, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Po-Shuan Huang, Cheng-Chih Chang, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin LPAL2 suppresses tumor growth and metastasis of hepatocellular carcinoma by modulating MMP9 expression Cells 11:2610,1-12, 2022. https://doi.org/10.3390/cells11162610 (SCI; IF: 7.666, 51/194=26.2 %, Cell Biology)

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2021

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  1. Hsiang-Wei Huang, Cheng-Chih Chang , Chia-Siu Wang and Kwang-Huei Lin. Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development Cells. 10:67. 2021 (SCI; IF: 6.600, 53/195=27.2 %, Cell Biology)

  2. Yang-Hsiang Lin, Meng-Han Wu, Yi-Chung Liu, Ping-Chiang Lyu, Chau-Ting Yeh, and Kwang-Huei Lin LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing Oncogene 40:4675–4685 2021 (SCI; IF: 9.867, 29/295=9.8%, Biochemistry & Molecular biology)

  3. Hsiang-Wei Huang, Ching-Ying Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang, Cheng-Chih Chang, and Kwang-Huei Lin CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer Oncogene 2021. DOI: 10.1038/s41388-021-02087-8 (SCI; IF: 9.867, 29/295=9.8%, Biochemistry & Molecular biology)

  4. Po-Shuan Huang, Chia-Jung Liao, Ya-Hui Huang, Chau-Ting Yeh, Cheng Yi Chen, Hui-Chi Tang, Cheng-Chih Chang, and Kwang-Huei Lin Functional and clinical significance of dysregulated microRNAs in liver cancer Cancers 13, 5361, 1-24, 2021 (SCI; IF: 6.639, 51/242=21.1 %, Oncology)

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2020

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  1. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh and Kwang-Huei Lin TUG1 is a regulator of AFP and serves as prognostic marker in non-hepatitis B non-hepatitis C hepatocellular carcinoma Cells 9(2): 262. doi: 10.3390/cells9020262. 2020 Jan 21 (SCI; IF: 6.600, 70/195=35.9%, cell Biology)

  2. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Yi-Hsin Tseng, Cheng Yi Chen, Tzu-Kang Lin, Chau-Ting Yeh and Kwang-Huei Lin Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer Cells 9(4):961. doi: 10.3390/cells9040961. 2020 Apr14 (SCI; IF: 6.600, 70/195=35.9%, cell Biology)

  3. Syuan-Ling Lin, Yang-Hsiang Lin, Hsiang-Cheng Chi, Tzu-Kang Lin, Wei-Jan Chen, Chau-Ting Yeh and Kwang-Huei Lin A Novel Long Non-Coding RNA-01488 Suppressed Metastasis and Tumorigenesis by Inducing miRNAs That Reduce Vimentin Expression and Ubiquitination of Cyclin E Cells 9(6):1504. doi: 10.3390/cells9061504. 2020 Jun 20 (SCI; IF: 6.600, 70/195=35.9%, cell Biology)

  4. Yu-Chin Liu, Chau-Ting Yeh and Kwang-Huei Lin Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies Cells 9(6):1331. doi: 10.3390/cells9061331. 2020 May 26 (Review; IF: 6.600, 70/195=35.9%, cell Biology)

  5. Cheng-Heng Wu, Cheng-Yi Chen, Chau-Ting Yeh and Kwang-Huei Lin Radiosensitization of Hepatocellular Carcinoma through Targeting Radio-Associated MicroRNA International Journal of Molecular Sciences 21(5):1859. doi: 10.3390/ijms21051859. 2020 Mar 9 (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

  6. Hsiang-Cheng Chi, Chung-Ying Tsai, Chia-Siu Wang, Huang-Yu Yang, Chien-Hui Lo, Won-Jing Wang, Kam-Fai Lee, Li-Yin Lai, Ji-Hong Hong, Yen-Fang Chang, Ming-Ming Tsai, Chau-Ting Yeh, Cheng Heng Wu, Ching-Chuan Hsieh, Lu-Hai Wang, Wei-Jan Chen and Kwang-Huei Lin DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits Oncogene 39(37):5933-5949. doi: 10.1038/s41388-020-01390-0. 2020 Sep 10 (SCI; IF: 9.867, 26/244=9.8%, Oncology)

  7. Cheng-Heng Wu, Chau-Ting Yeh and Kwang-Huei Lin Thyroid hormones suppress FOXM1 expression to reduce liver cancer progression Oncology Reports 44(4):1686-1698. doi: 10.3892/or.2020.7716 2020 Oct (SCI; IF: 3.906, 115/244=47.1%, Oncology)

  8. Huang PS, Chang CC, Wang CS, Kwang-Huei Lin Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer. Biomed J. (20)30143-30148. 2020 (SCI; IF: 4.910, 108/311=34.7 %, Biochemistry & Molecular Biology)

  9. Yu-De Chu, Wey-Ran Lin, Yang-Hsiang Lin, Wen-Hsin Kuo, Chin-Ju Tseng, Siew-Na Lim, Yen-Lin Huang, Shih-Chiang Huang, Ting-Jung Wu, Kwang-Huei Lin, Chau-Ting Yeh COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma Cancers 12(6):1646. 2020 (SCI; IF: 6.639, 51/242=21.1 %, Oncology)

  10. Yang-Hsiang Lin, Kwang-Huei Lin, Chau-Ting Yeh Thyroid Hormone in Hepatocellular Carcinoma: Cancer Risk, Growth Regulation, and Anticancer Drug Resistance Front Med 7:174. 2020 (SCI; IF: 5.093, 28/167=16.8%, Medicine, General & Internal)

  11. Chih-Lang Lin, Rong-Nan Chien, Yu-De Chu, Kung-Hao Liang, Ya-Hui Huang, Po-Yuan Ke, Kwang-Huei Lin, Yang-Hsiang Lin, Chau-Ting Yeh Hepatitis B virus X gene mutants emerge during antiviral therapy and increase cccDNA levels to compensate for replication suppression Hepatol Int. 14(6):973-984. 2020 (SCI; IF: 6.047, 24/92=34.7 %, Gastroenterology & Hepatology)

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2019

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  1. Chen CY, Wu SM, Lin YH, Chi HC, Lin SL, Yeh CT, Chuang WY, Lin KH Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer Theranostics 9(8):2361-2379. doi: 10.7150/thno.29628. eCollection 2019 Apr 13 (SCI; IF:11.556, 10/136=7.4%, Medicine, Resarch & Experimental)

  2. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh, and Kwang-Huei Lin Molecular functions and clinical impact of thyroid hormone- triggered autophagy in liver-related diseases Journal of Biomedical Science 26(1):24. doi: 10.1186/s12929-019-0517-x. 2019 Mar 8 (SCI, IF:8.41, 20/136=14.7% Medicine, Research & Experimental)

  3. Yu-Chin Liu, Chau-Ting Yeh, and Kwang-Huei Lin Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis International Journal of Molecular Sciences 20(20). 4986.(page 1-27) doi: 10.3390/ijms20204986. 2019 Oct 9 (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

  4. Po-Shuan Huang, Chia-Siu Wang, Chau-Ting Yeh, and Kwang-Huei Lin Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma International Journal of Molecular Sciences 20(20). 5220.(page 1-24) doi: 10.3390/ijms20205220. 2019 Oct 21 (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

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2018

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  1. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and Kwang-Huei Lin The impact of DNA and RNA methylation on radiobiology and cancer progression International Journal of Molecular Sciences 19(2). pii: E555. doi: 10.3390/ijms19020555. 2018 Feb (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

  2. Chung-Ying Tsai, Hsiang-Cheng Chi, Lang-Ming Chi, Huang-Yu Yang, Ming-Ming Tsai, Kam-Fai Lee, Hsiang-Wei Huang, Li-Fang Chou, Ann-Joy Cheng, Chih-Wei Yang, Chia-Siu Wang and Kwang-Huei Lin Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy FASEB Journal 32(5):2601-2614. doi: 10.1096/fj.201700094R. 2018 May (SCI; IF:5.192, 9/93=9.7%, Biology)

  3. Po-Shuan Huang, I-Hsiao Chung, Yang-Hsiang Lin, Tzu-Kang Lin, Wei-Jan Chen and Kwang-Huei Lin The long non-coding RNA MIR503HG enhances proliferation of human ALK-negative anaplastic large-cell lymphoma International Journal of Molecular Sciences 19(5):1463; doi:10.3390/ijms19051463 2018 May (SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

  4. Chen TH, Chiu CT, Lee C, Chu YY, Cheng HT, Hsu JT, Wu RC, Yeh TS, Lin KH Circulating microRNA-22-3p Predicts the Malignant Progression of Precancerous Gastric Lesions from Intestinal Metaplasia to Early Adenocarcinoma Digestive diseases and sciences  63(9) 2301–2308. doi: 10.1007/s10620-018-5106-4. 2018 Sep (SCI; IF: 2.751, 57/88=64.8%, Gastroenterology & Hepatology)

  5. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Hsiang-Cheng Chi, Chung-Ying Tsai, Wen-Yu Chuang, I-Hsiao Chung, Ching-Ying Chen, Chia-Jung Yu, and Kwang-Huei Lin Thyroid hormone negatively regulates tumorigenesis through suppression of BC200 Endocrine-Related Cancer 25 (12), 967-979, 2018 Dec (SCI; IF: 5.678, 22/124=17.7%, Endocrinology & Metabolism)

  6. Yang-Hsiang Lin, Meng-Han Wu, Chau-Ting Yeh, and Kwang-Huei Lin Long non-coding RNAs as mediators of tumor microenvironment and liver cancer cell communication International Journal of Molecular Sciences 19 (12). pii: E3742. doi: 10.3390/ijms19123742. 2018 Nov (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

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2017

 

  1. Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung     Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, and K-H Lin (corresponding author)  Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression. Int. J. Cancer 140(7):1581-1596. 2017.  doi: 10.1002/ijc.30559. (SCI; IF: 7.396, 59/244=24.2%, Oncology)

  2. I-Hsiao Chung, Pei-Hsuan Lu, Yang-Hsiang Lin, Ming-Ming Tsai, Yun-Wen Lin, Chau-Ting Yeh and K-H Lin (corresponding author) The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma. Sci Rep.  7(1), 295, 2017. doi: 10.1038/s41598-017-00382-7. (SCI; IF: 4.38, 17/71=23.9%, multidisciplinary sciences)

  3. Hsiang-Cheng Chi, Shen-Liang Chen, Syuan-Ling Lin, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Chau-Ting Yeh and K-H Lin (corresponding author) Thyroid hormone protect hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. Oncogene 36(37):5274-5284 2017 doi: 10.1038/onc.2017.136. (SCI; IF: 9.867, 26/244=9.8%, Oncology)

  4. Tzu-Kang Lin, Chang-Nen Chang, Cheng-Shian Tsai, Yin-Cheng Huang, Yu-Jen Lu, Wei-Jan Chen, Yang-Hsiang Lin, I-Hsiao Chung and K-H Lin (corresponding author) The long non-coding RNA LOC441204 enhances cell growth in human glioma. Sci Rep. 7 (1), 5603, 2017. doi: 10.1038/s41598-017-05688-0. (SCI; IF: 4.38, 17/71=23.9%, multidisciplinary sciences)

  5. Hsiang-Cheng Chi , Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and K-H Lin  Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells. Int. J. Mol. Sci. 2017 (review; SCI; IF: 4.38, 74/297=24.9%, Biochemistry & Molecular Biology)

  6. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Pei-Yu Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang (co-corresponding author) and Kwang-Huei Lin Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214. Sci Rep. 7(1):14868. doi: 10.1038/s41598-017-14864-1. 2017 Nov 1 (SCI; IF: 4.38, 17/71=23.9%, multidisciplinary sciences)

  7. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Mei-Ling Cheng, Hsiang-Cheng Chi, Chung-Ying Tsai, I-Hsiao Chung, Ching-Ying Chen and Kwang-Huei Lin Taurine up-regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma Hepatology  67(1):188-203.  doi: 10.1002/hep.29462  2018 Jan  (SCI; IF:17.425, 6/88=6.8%, Gastroenterology & Hepatology)

  8. Syuan-Ling Lin, Sheng-Ming Wu, I-Hsiao Chung , Yang-Hsiang Lin, Ching-Ying Chen, Hsiang-Cheng Chi , Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Stimulation of interferon-stimulated gene 20 by thyroid hormone enhances angiogenesis in liver cancer Neoplasia  20(1):57-68.  doi: 10.1016/j.neo. 2017.10.007  2018 Jan (SCI; IF:5.715, 48/244=19.7%, Oncology )

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2016

 

  1. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin (corresponding author) Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer. Int. J. Mol. Sci., 17(6), 945, 2016 (review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

  2. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin (corresponding author)  Circulating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer. Eur. J Cancer Accepted. (SCI; IF: 9.162, 31/244=12.7%, Oncology)

  3. Hsiang-Cheng Chi, Shen-Liang Chen, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Sheng-Ming Wu, Cheng-Pu Sun, Chau-Ting Yeh and Kwang-Huei Lin (corresponding author)Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1 dependent selective. Autophagy 12(12): 2271-2285, 2016 (SCI; IF: 16.016, 22/195=11.3%, Cell Biology)

  4. Hsiang-Cheng Chi, Shen-Liang Chen, Yi-Hung Cheng, Tzu-Kang Lin, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Ya-Hui Huang and K-H Lin (corresponding author)  Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death & Disease 4;7(8):2016 (SCI; IF: 8.469, 40/195=20.5% Cell Biology)

  5. Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, and K-H Lin (corresponding author)  Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression. Int. J. Cancer 2016 Dec 7. doi: 10.1002/ijc.30559. (SCI; IF:7.396, 29/213=13.6%, Oncology)

  6. Tseng YH, Huang YH, Lin TK, Wu SM, Chi HC, Tsai CY, Tsai MM, Lin YH, Chang WC, Chang YT, Chen WJ, and K-H Lin (corresponding author) Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma. Sci Rep. 9; 6:38756. 2016. (SCI; IF:4.38, 7/63=11.1%, multidisciplinary sciences)

 

2015

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  1. Sheng-Ming Wu, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Yi-Hsin Tseng, Chung-Ying Tsai, Ching-Ying Chen, Syuan-ling Lin, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Ying F. Huang, Ming-Huang Chen, Yi-Chen Yeh and K-H Lin (corresponding author) Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth. Inter. J. Cancer 137:37-49, 2015  (SCI; IF:7.396, 29/213=13.62%, Oncology)

  2. Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, Ya-Hui Huang, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Ming-Ming Tsai,Ching-Ying Chen, Tina P. Lin, Yung-Hsin Yeh, Wei-Jan Chen and K-H Lin (corresponding author) Repression of microRNA-130b by thyroid hormone enhances cell motility. J Hepatology 62:1328-1340,2015 (SCI; IF: 25.083, 5/79=6.33% Gastroenterology & Hepatology)

  3. Cheng-Yi Chen, Chie-Pein Chen, and K-H Lin (corresponding author) Biological Functions of Thyroid Hormone in Placenta. Int. J. Mol. Sci.16(2): 4161-4179, 2015 (review; SCI; IF: 5.924, 52/163=31.90%, Chemistry, multidisciplinary)

  4. Chia-Jung Liao, Hsiang-Cheng Chi, Chung-Ying Tsai, Chi-De Chen, Sheng-Ming Wu, Yi-Hsin Tseng, Yang-Hsiang Lin, I-Hsiao Chung, Ching-Ying Chen, Syuan-Ling Lin, Ya-Hui Huang, and K-H Lin (corresponding author) A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis. Oncotarget 6(11)9341-54,2015 (SCI; IF: 5.008, 36/213=16.90% , Oncology)

  5. I-Hsiao Chung, Cheng-Yi Chen, Yang-Hsiang Lin, Hsiang-Cheng Chi, Ya-Hui Huang, Pei-Ju Tai, Chia-Jung Liao, Chung-Ying Tsai, Syuan-Ling Lin, Meng-Han Wu, Ching-Ying Chen and K-H Lin  (corresponding author) Thyroid hormone-Mediated Regulation of Lipocalin 2 through the Met/FAK Pathway in Liver Cancer. Oncotarget 6(17) 15050-64, 2015 (SCI; IF: 5.008, 36/213=16.90%, Oncology)

　

2014

 

  1. Yi-Hsin Tseng, Po-Yuan Ke, Chia-Jung Liao, Sheng-Ming Wu, Hsiang-Cheng Chi, Chung-Ying Tsai, Cheng-Yi Chen, Yang-Hsiang Lin, and K-H Lin (corresponding author) Chromosome 19 Open Reading Frame 80 Is Upregulated by the Thyroid Hormone and Modulates Autophagy and Lipid Metabolism. Autophagy  10(1), 20-31, 2014 (SCI; IF: 9.108 , 19/187=10.16%; Cell Biol.)

  2. Chung-Ying Tsai, Chia-Siu Wang, Ming-Ming Tsai, Hsiang-Cheng Chi, Wan-Li Cheng, Yi-Hsin Tseng, Cheng-Yi Chen, Crystal D. Lin, Jun-I Wu, Lu-Hai Wang, and K-H Lin (corresponding author)  Interleukin 32 Increases Human Gastric Cancer cell invasion Associated with Tumor Progression and Metastasis. Clinical Cancer Res. 20(9), 2276-88, 2014.  (SCI; IF: 8.738, 12/213=5.63%, Oncology)

  3. Cheng-Yi Chen, I-Hsiao Chung, Ming-Ming Tsai, Yi-Hsin Tseng, Hsiang-Cheng Chi, Chung-Ying Tsai, Yang-Hsiang Lin, You-Ching Wang, Tzu-I Wu, Chau-Ting Yeh, Dar-In Tai4 and K-H Lin (corresponding author) Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling. Mol. Cancer 13:162, 2014(SCI; IF: 5.888, 25/213=11.74%, Oncology)

  4. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Cheng-Yi Chen, Hsiang-Cheng Chi, Yi-Hsin Tseng, Pei-Jung Chung , Yang-Hsiang Lin, I-Hsiao Chung, Ching-Ying Chen and K-H Lin (corresponding author) microRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer. Cancer lett. 351:222-231, 2014 (SCI; IF: 5.992, 23/213=10.80%, Oncology)

  5. Chia-Jung Liao, Tzu-I Wu, Ya-Hui Huang, Ting-Chang Chang, Chyong-Huey Lai, Shih-Ming Jung, Chuen Hsueh and K-H Lin (corresponding author) Glucose-regulated protein 58 modulates β-catenin protein stability in a cervical adenocarcinoma cell line. BMC Cancer  14:555, 2014 (SCI; IF: 3.265, 85/213=39.91%, Oncology)

  6. Tsai MM, Wang CS, Tsai CY, Chi HC, Tseng YH, H K-Lin (corresponding author) Potential prognostic, diagnostic and therapeutic markers for human gastric cancer. World J Gastroenterol.20(38): 13791-13803, 2014. (review; SCI; IF: 2.787 , 38/79=48.10% , GASTROENTEROLOGY & HEPATOLOGY)

  7. Y-H Tseng, Y-H Yeh, W-J Chen, and K-H Lin (corresponding author) Emerging Regulation and Function of Betatrophin. Int. J. Mol. Sci. 15(12), 23640-23657, 2014 (review; SCI; IF: 3.257, 52/163=31.90%, CHEMISTRY, MULTIDISCIPLINARY)

　

2013

 

  1. Ya-Hui Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Chen-Hsin Liao, Chia-Jung Liao, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, Sheng-Yen Lin, Yu-Ting Hung, Chih-Jen Wang, Crystal D. Lin and K-H Lin (corresponding author) Thyroid hormone regulation of miR-21 enhances migration and invasion of human hepatoma cells. Cancer Res. 73(8) 2505-17, 2013 (SCI; IF: 8.556, 13/213=6.1% Oncology)

  2. Sheng-Ming Wu, Wan-Li Cheng, Crystal D. Lin and K-H Lin (corresponding author) Thyroid hormone actions in liver cancer. Cell & Mol Life Sci. 70 (11), 1915-1936, 2013 (SCI; IF: 5.694, 40/289=13.84% Biochem & Mol Biol.)

  3. Yang-Hsiang Lin, Ya-Hui Huang, Meng-Han Wu, Sheng-Ming Wu, Hsiang-Cheng Chi, Chia-Jung Liao, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, Ming-Ming Tsai and K-H Lin (corresponding author) Thyroid hormone suppresses cell proliferation through endoglin-mediated promotion of p21 stability. Oncogene 32 (August), 3904-3914, 2013. (SCI; IF: 7.932, 15/213=7.04% Oncology)

  4. Yang-Hsiang Lin, Chia-Jung Liao, Ya-Hui Huang, Meng-Han Wu, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Tzu-I, Wu, Ming-Ming Tsai, rystal D. Lin, and K-H Lin (corresponding author) Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells. Oncogene 32 (38), 4509-4518, 2013.  (SCI; IF: 7.932, 15/213=7.04 Oncology)

  5. Cheng Yi Chen; Ming Ming Tsai; Hsiang Cheng Chi; K-H Lin (corresponding author) Biological significance of a thyroid hormone-regulated secretome. BBA- Proteins and Proteomics(invited article) 1834(11), 2271-2284, 2013. (SCI; IF: 3.016, 25/72=34.72% Biophysics)

  6. Hsiang Cheng Chi, Cheng-Yi Chen, Ming-Ming Tsai, Chung-Ying Tsai, K-H Lin (corresponding author) Molecular functions of thyroid hormones and their clinical significance in liver-related diseases. J of Biomed. Biotechnol (invited article).  2013, 1-6, 2013 (SCI; IF:2.134, 81/161=50.31% Biotechnology & Applied Microbiology)

  7. Hsiang-Cheng Chi, Chen-Hsin Liao, Ya-Hui Huang, Sheng-Ming Wu, Chung-Ying Tsai, Chia-Jung Liao, Yi-Hsin Tseng, Yang-Hsiang Lin, Cheng-Yi Chen , I-Hsiao Chung, Tzu-I Wu, Wei-Jan Chen, K-H Lin (corresponding author) Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4. Biochem. Bioph. Res. Co. 439 (1), 60-65, 2013 (SCI; IF: 2.371, 35/72=48.61% Biophysics)

 

2012

 

  1. Cheng-Yi Chen, Lang-Ming Chi, Hsiang-Cheng Chi, Ming-Ming Tsai, Chung-Ying Tsai, Yi-Hsin Tseng, Yang-Hsiang Lin, Wei-Jan Chen, K-H Lin (corresponding author) Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-based quantitative proteomics study of a thyroid hormone-regulated secretome in human hepatoma cells. Mol. Cell. Proteomics 11(4): 10.1074/mcp.M111.011270, 1-19, 2012 (SCI; IF: 5.912, 6/77=7.79%)

  2. Chen-Hsin Liao, Chau-Ting Yeh,Ya-Hui Huang, Sheng-Ming Wu, Hsiang-Cheng Chi, Ming-Ming Tsai, Chung-Ying Tsai, Chia-Jung Liao, Yi-Hsin Tseng,Yang-Hsiang Lin, Cheng-Yi Chen, I-Hsiao Chung, Wan-Li Cheng, Wei-Jan Chen, K-H Lin (corresponding author) Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells. Hepatology 55(3):910-20, 2012 (SCI; IF:11.711, 4/79=5.06%)

  3. Ming-Ming Tsai, Paul Y. Lin, Wan-Li Cheng, Chung-Ying Tsai, Hsiang-Cheng Chi, Cheng-Yi Chen, Yi-Hsin Tseng, Yi-Fen Cheng, Chi-De Chen, Ying Liang, Chia-Jung Liao, Sheng-Ming Wu, Yang-Hsiang Lin, I-Hsiao Chung, Chia-Siu Wang, and K-H Lin (corresponding author) Overexpression of ADP-Ribosylation factor 1 in Human Gastric Carcinoma and its Clinicopathological Significance. Cancer Science doi: 10.1111/j.1349-7006.2012.02243.x, 2012 (SCI; IF: 3.896, 62/213=29.11% )

  4. Wan-Li Cheng, Ming-Ming Tsai, Chung-Ying Tsai, Ya-Hui Huang, Cheng-Yi Chen, Hsiang-Cheng Chi, Yi-Hsin Tseng, Im-Wai Chao, Wei-Chi Lin, Sheng-Ming Wu, Ying Liang4, Chia-Jung Liao1, Yang-Hsiang Lin1, I-Hsiao Chung, Wei-Jan Chen, Paul Y. Lin, and Chia-Siu Wang, K-H Lin (corresponding author) Glyoxalase-I is a novel prognosis factor associated with gastric cancer progression. PLoS ONE 7(3): e34352. doi:10.1371/journal.pone.0034352 (SCI; IF: 3.057, 11/63=17.46%, Biology)

  5. Hsiang-Cheng Chi, Shen-Liang Chen, Chen-Hsin Liao,Ya-Hui Huang,Ming-Ming Tsai,Chau-Ting Yeh, Sheng-Ming Wu, Chia-Jung Liao, Yi-Hsin Tseng, Yang-Hsiang Lin,Cheng-Yi Chen, Chung-Ying Tsai, I-Hsiao Chung,Wan-Li Cheng,Wei-Jan Chen, K-H Lin (corresponding author) A novel function of thyroid hormone receptors in promoting metastasis of human hepatoma cells via regulation of TRAIL. Cell Death and Differentiation, 19 (10): 1802-1814 2012. doi:10.1038/cdd.2012.58 (SCI; IIF: 8.218, 23/289=7.96%)

  6. Wan-Li Cheng, Chia-Siu Wang, Ming-Ming Tsai1, and K-H Lin (corresponding author) Biomarkers and Oncogenic Pathways in Gastric Cancer. Adaptive Medicine 4(3):125-131, 2012.

  7. Huang YH, Lin KH, Liao CH, Lai MW, Tseng YH, Yeh CT Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma. PLoS ONE 2012;7(7): e40738. doi: 10.1371/journal.pone. 0040738. (SCI; IF: 3.057, 11/63=17.46% , Biology)

  8. Huang YH, Lin KH, Chen HC, Chang ML, Hsu CW, Lai MW, Chen TC, Lee WC, Tseng YH, Yeh CT Identification of postoperative prognostic microRNA predictors in hepatocellular carcinoma. PLoS ONE 2012;7(5):e37188. doi: 10.1371/journal.pone. 0037188. (SCI; IF: 3.057, 11/63=17.46%, Biology)

 

2011

 

  1. C-J Liao, T-I Wu, Y-H Huang, T-C Chang, C-S Wang, M-M Tsai, C-Y Hsu, M-H Tsai, C-H Lai, and *K-H Lin Overexpression of gelsolin in human cervical carcinoma and its clinicopathological significance. Gynecology oncology 2011 120:135-144 (SCI; IF: 4.198, 7/80=8.75%)

  2. S-M Wu, Y-H Huang, Ch-T Yeh, M-M Tsai, C-H Liao, W-L Cheng ,W-J Chen , *K-H Lin Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells. Oncogene 2011 30:2057-2069 (SCI; IF:7.932, 15/213=7.04%)

  3. W-J Chen, Y-H Chen, K-H Lin, C-H Ting, Y-H Yeh Cilostazol Promotes Vascular Smooth Muscles Cell Differentiation Through the cAMP Response Element-Binding Protein-Dependent Pathway. Arterioscl Throm Vas (SCI; IF:5.969, 4/63=6.3%)

  4. W-J Chen, Y-H Yeh, K-H Lin, G-J Chang, C-T Kuo Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism. Basic Res Cardiol. In Press 2011 (SCI; IF: 6.008, 11/124=8.9% )

  5. W-L Cheng, C-S Wang, Y-H Huang, M-M Tsai, Y Liang, and *K-H Lin Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer. Annals oncology 22:2267-2276, 2011 (SCI; IF: 9.269, 11/213=5.16%)

  6. C-J Liao, T-I Wu, Y-H Huang, T-C Chang, C-S Wang, M-M Tsai, C-H Lai, Y Liang, and *K-H Lin Glucose-regulated protein 58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer. Cancer Science 102:2255-2263, 2011 (SCI; IF: 3.896, 62/213=29.11%)

 

2010

 

  1. Chen WJ, Pang JH, Lin KH, Lee DY, Hsu LA, Kuo CT  Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction. Basic Res Cardiol. 2010 105:19-28 (SCI; IF:6.128, 8/114=7%)

  2. Y-H Huang, C-H Liao, R-N Chen, C-J Liao, *K-H Lin Human testicular orphan receptor 4 enhances thyroid hormone receptor signaling. J cell physiol. 2010 222(2):347-356 (SCI; IF:3.986, 13/77=16.88%)

  3. C-H Liao, S-C Yeh, Y-H Huang, R-N Chen, M-M Tsai, W-J Chen, H-C Chi, P-J Tai, C-J Liao, S-M Wu, W-L Cheng , L-M Pai, *K-H Lin Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion. Endocrine-Related Cancer 2010 17:99-111 (SCI; IF:4.432, 40/184=21.7%)

  4. S-M Wu, Y-H Huang, Y-h Lu, L-F Chien, C-T Yeh ,C-S Liao, M-m Tsai, W-J Chen, C-J Liao, W-L Cheng , *K-H Lin Thyroid hormone receptor mediated regulation of methionine adenosyltransferase 1gene is associated with cell invasion. Cell & Mol Life Sci. 2010 Jun ; 67(11):1831-1843 (SCI; IF:7.047, 35/286=12.2%)

 * Corresponding Author

 

 

Publications: (1984-2009)

 

  1. Lin, K-H., Winter, A.L. and Lindahl, R.: Aldehyde dehydrogenase activity in five rat hepatoma cell lines.  Cancer Research **44: 5219-5226, 1984.

  2. Lin, K-H., Leach, M.F., Winter, A.L. and Lindahl, R.: Characteristics and aldehyde dehyhrogenase activity of four rat hepatoma cell lines produced by diethynitrosamine-phenobarbital treatment.  In Vitro Cellular & Develop. Biol. ** 22: 263-272, 1986.

  3. Lin, K-H., and Lindahl R.: Role of aldehyde dehydrogenase activity in cyclophosphamide metabolism in rat hepatoma cell lines.  Biochem. Pharmacol**. 36: 3305-3307, 1987.

  4. Lin, K-H., Brennan, M., and Lindahl, R.: Expression of tumor associated aldehyde dehydrogenase gene in rat hepatoma cell lines, Cancer Research** 48: 7009-7012, 1988.

  5. Chapekar, MS., Hugget, AC., Cheng, CC., Hampto, LL., Lin, K-H., Thorgeirsson SS.  Isolation and characterization of a rat liver epithelial cell line resistant to the antiproliferative effects of transforming growth factor beta (type 1).  Cancer Reserch; ** 50: 3600-3604, 1990.

  6. Lin, K-H., Fukuda, T. and Cheng, S-y.: Large scale purication of an active thyroid hormone nuclear receptor expressed in Escherichia coli J. Biol. Chem**. 265: 5161-5165, 1990.

  7. Lin, K-H., Willingham, M.C., Liang, C-M and Cheng, S-y. Intracellular distribution of the endogenous and transfected b form of thyroid homone nuclear receptor visualized by the use of domain-specific monoclonal antibodies.  Endocrinology**. 128(5): 2601-2609, 1991.

  8. Lin, K-H., and Cheng, S-y.  Zn+2 indues reversible crossing-linking of human placetal thyroid hormone nuclear receptor with no effect on hormone binding.  Biochem. Biophy. Res. Comm**. 175:250-255, 1991.

  9. Lin, K-H., Parkison, C., McPhie, P., and Cheng, S-y. An essential role of domain D in the hormone binding activity of human b1 thyroid hormone nuclear receptor.  Molecular Endocrinology**. 5(4): 485-492, 1991

  10. Lin, K-H., and Cheng, S-y. Zn(II) and other divalent cations induce reversible cross-linking of human hormone alpha1 nuclear receptor with no effect on hormone binding.  Proc10thInternational Thyroid Conference 865-868, 1991.

  11. Lin, K-H., and Cheng, S-y., An efficient method to purify active eukaryotic proteins from the inclusion bodies in Escherichia coli. BioTechniques. ** 11, 748-753, 1991.

  12. Ashizawa, K., MacPhie, P., Lin, K-H., and Cheng, S-y.  An in vitro novel mechnism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose-1, 6-bisphosphate.Biochem. ** 30, 7105-7111, 1991.

  13. Parkison, C., Ashizawa, K., McPhie, P., Lin, K-H., and Cheng, S-y. The enzymatic and thyroid hormone binging activity of the monomer of pyruvate kinase, subtype M1 expressed in Escherichia Coli. Biochem. Biophy. Res. Comm. ** 179, 668-674, 1991.

  14. Lin, K-H., Kiyoto Ashizawa, and Sheue-yann Cheng.  Phosphorylation stimulates the transcriptional activity of the human b1 thyroid hormone nuclear receptor. Proc. Natl. Acad. Sci. ** 89, 7737-7741, 1992.

  15. Lin, K-H, (corresponding author) Ya-wen Lin, Clifford Parkison, and Sheue-yann Cheng. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpression beta 1 thyroid hormone receptor.  Cancer letts. ** 85: 189-194, 1994.

  16. Chang, K.S.S., Lin, C-I, Ling, P., Lin, K-H. Lin, H-C., and Twu, S-J. Molecular subtypes of env sequences around V3 region of human immunodeficiency virus types1 in Taiwan.  Eur. J. Epidemiology ** 10: 247-250. 1994.

  17. Liu, T-Z., Chen, P-Y., Chiu, D.T-Y., Wei, J-S., Chang, K.S.S., and Lin, K-H. (corresponding author) Detection of a novel lactate dehydrogenase isoenzyme and an apparent differentiation-associated shift in isoenzyme profile in hepatoma cell lines.  Cancer letts** 87: 193-198 1994.

  18. Lin, K-H, (corresponding author) Lin, Y-W., Mcphie, P., Cheng, S-y. Over expression of thyroid hormone b1 nuclear receptor is associated with an increased proliferation of human hepatoma cells. Proceeding XVI of the International Cancer Congress: 615-622, 1994.

  19. Wang, Chih-Jen, Howng, Shen-Long, Lin, K-H. Expression of the thyroid hormone receptors in human pituitary tumors cells. Cancer letts**. 91: 79-83, 1995.

  20. Hsu, M.-L., Chen, S.-W., Lin, K.-H., Liao, S.-K. and Chang. K.S.S. Cytokine regulation of HIV-l LTR trans-activation in human hepatocellular carcinoma cell lines. Cancer letts **. 94: 41-48, 1995

  21. Lin, K-H, (corresponding author) Ya-wen Lin, Hui-fang Lee, Szu-Tah Chen, Kenneth S.S. Chang and Sheue-yann Cheng. Increased metastatic potential of the poorly differentiated human hepatocellular carcinoma cells is associated with an overexpression of the thyroid hormone beta1 nuclear receptor and low expression of the nm23 gene. Cancer letts ** 98: 89-95, 1995.

  22. Lin, K.H, (corresponding author) Zhu, X-G, Shieh, H-y, Hsu, H-C, Chen, S-T, McPhie, P. and Cheng,S-y. Identification of naturally occurring dominant negative mutants of thyroid hormone alpha1 and beta1 receptors in a human hepatocellular carcinoma cell line. Endocrinology**. 137, 4073-4081,1996.

  23. Zhu, X-G., McPhie, P., Lin, K.H, and Cheng,S-y The differential hormone-dependent transcriptional activation of thyroid hormone receptor isoforms is mediated by interplay of their domains. J. Biol. Chem**.  272: 9048-9054. 1997.

  24. Lin, K-H, (corresponding author) Shen-Liang Chen, Xu-Guang Zhu, Hsing-ying Shieh, Peter McPhie, and Sheue-yann Cheng The gene regulating activity of thyroid hormone nuclear receptor is modulated by cell-type specific factors. Biochem. Biophy. Res. Comm**. 238, 280-284, 1997.

  25. Lin, K-H, (corresponding author) Xu-Guang Zhu, Hai-Chu Hsu, Shen-Liang Chen, Hsing-ying Shieh,  Szu-Tah Chen, and Sheue-yann Cheng Domiant negative activity of mutant thyroid hormone alpha1 receptors from patients with hepatocellular carcinoma. Endocrinology**.  138, 5308-5315,1997.

  26. Wang. C-S., Lin, K-H.,(corresponding author) Hsu, Y-C., Hsueh, S. Distant metastasis of gastric cancer is associated with elevated expression of the antimetastatic nm23 gene. Cancer letters ** 128: 23-29, 1998.

  27. K-H Lin, (corresponding author) Hsing-Ying Shieh, Shen-Liang Chen and Hai-Chu Hsu Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells.  Mol. Carcinogenesis** 26: 53-61, 1999.

  28. Chen, ST, Shieh, Hy, Lin, JD, Chang, KSS  Lin, K-H (corresponding author) Overexpression of thyroid hormone receptor  beta 1 induces the expression of thyrotropin receptor and cell proliferatiojn in human thyroid carcinoma cells. J. Endocrinology (SCI; IF: 2.879) 165:379-389, 2000

  29. Lin, K-H (corresponding author), H-y Shieh, H-C Hsu, Negative regulation of the anti-metastatic gene Nm23-H1 by thyroid hormone receptors. Endocrinology. 141: 2540-2547, 2000.(SCI; 4.959, 20/93=21.5%).

  30. Chen,W-J, Lin, K-H  (corresponding author) Lee, Y-S Molecular characterization of myocardial fibrosis during hypothyroidism. Evidence for negative regulation of the pro alpha1(I) collagen gene expression by thyroid hormone receptor.  Mol. Cell. Endocrinology 162, 45-55, 2000. (SCI; IF: 2.689) 29/88

  31. Lin, K-H (corresponding author),Wu, Y-S and Chen, S-L  Impaired interaction of mutant thyroid hormone receptors associated with humahepatocellular carcinoma with transcriptional coregulators. Endocrinology 142: 653-662, 2001. (SCI; 4.959, 20/93=21.5%)

  32. Wang. C-S., Lin, K-H (corresponding author). Freguent alteration of thyroid hormone receptor alpha-1 gene in human gastric cancers. Cancer Letter 25;175(2):121-127. 2002. (SCI; IF: 3.504) 46/114

  33. K-H Lin (corresponding author), Won-Jing Wang, Yi-Shing Wu and Sheue-yann Cheng  Activation of antimetastatic Nm23-H1 gene expression by estrogen and its alpha-receptor.Endocrinology, 143: 467-475. 2002. (SCI; 4.959, 20/93=21.5%).

  34. S-T Chen, J-D Lin, and K-H Lin Characterization of a thyroid hormone-mediated short-loop feedback control of thyrotropin receptor gene in an anaplastic human thyroid cancer cell line. J. Endocrinol. 2002 Nov; 175(2):459-65. (SCI; IF: 2.879)

  35. Shen Liang Chen, Yu Jung Chang, Y Hsin Wu, and K-H Lin (corresponding author) Hormone induced degradation of thyroid hormone receptor is repressed by mitogen-activated protein kinase. Endocrinology 144(4):1407-1419. 2003.(SCI; 4.959, 20/93=21.5%).

  36. SY Hsieh, SF Liaw, SN Lee, PS Hsieh, K-H Lin, CM Chu, and YF Law Aberrant capase-activated Dnase(CAD) transcripts in human hepatoma cells. Brit. J. Cancer. 88:210-216, 2003.(SCI; IF: 4.155, 32/123).

  37. Chen, S-L, Wu, Y-S, Shieh, H-Y, K-H Lin (corresponding author) p53 is a regulator of the metasatasis suppressor gene-Nm23-H1 Molecular Carcinogenesis. 36:204-214, 2003. (SCI; IF: 2.806) 37/114

  38. K-H Lin (corresponding author), Hung-Yang Lee, Chung-Hsuan Shih, Chun-Che Yen , Shen-Liang Chen, Rong-Chi Yang, and Chia-Siu Wang. Plasma Protein Regulation by Thyroid Hormone J. Endocrinol. 179: 367-377, 2003. (SCI; IF: 2.879) 26/88

  39. Chung-hsuan Shih, Shen-Liang Chen, Chun-Che Yen, Ya-Hui Huang, Yun-Shien Lee, K-H Lin (corresponding author) Thyroid Hormone Receptor Dependent Transcriptional Regulation of Fibrinogen and Coagulation Proteins. Endocrinology Jun;145 (6):2804-2814, 2004. (SCI; 4.959, 20/93=21.5%)

  40. W-J Chen, Lin, K-H, Ying-Ju Lai; S-HYang; J-H S. Pang Protective Effect of Propylthiouracil Independent of Its Hypothyroid Effect on Atherogenesis in Cholesterol-Fed Rabbits: PTEN Induction and Inhibition of Vascular Smooth Muscle Cell Proliferation and Migration. Circulation, 110:1313-1319 2004. (SCI; IF: 12.563, 1/71)

  41. K-H Lin (corresponding author), Chia-yu Chen, Shen-Liang Chen, Chung-hsuan Shih, Chun-Che Yen, Ya-Hui Huang, Jiann-Jong Shen, Rong-Chi Yang, and Chia-Siu Wang Regulation of Fibronectin by Thyroid Hormone Receptor J Molecular Endocrinology. 33: 445-458, (SCI; IF: 3.855, 19/87). 2004.

  42. C-S Wang, K-H Lin (corresponding author), S-L Chen, Y-F Chan, S. H sueh Overexpression of SPARC Gene in Human Gastric Carcinoma and Its Clinicopathological Significance British J. Cancer 91: 1924-1930, 2004. (SCI; IF: 4.155, 32/123)

  43. C-C Yen, Y-H Huang, C-Y Liao, C-J Liao, W-L Cheng,W-J Chen , *K-H Lin Mediation of the inhibitory effect of thyroid hormone on proliferation of hepatoma cells by transforming growth factor-beta. J. Molecular Endocrinology 2006 Feb ; 36(1) : 9-21 (SCI; IF:3.628, 37/116=31.89%)

  44. Y-H Huang, C-Y Lee, P-J Tai, C-C Yen, C-Y Liao, W-J Chen, C-J Liao, W-L Cheng, R-N Chen, S-M Wu, C-S Wang and *K-H Lin Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones. Endocrinology 2006 May ; 147(5) : 2481-2489 (SCI; IF:4.993, 20/116=17.2%)

  45. Chang, J-H., Lin, K-H., Shih, C-H., Chang, Y-J., Chi,C-H., and Chen, S-L Myogenic Basic Helix-Loop-Helix Proteins Regulate the Expression of Peroxisomal Proliferator Activated Receptor-γ Coactivator-1α. Endocrinology 2006 June ; 147(6) : 3093-3106 (SCI; IF:4.993, 20/116=17.2%)

  46. C-D Chen, C-S Wang, Y-H Huang, K-Y Chien, Y Liang, W-J Chen, * K-H Lin Overexpression of CLIC1 in Human Gastric Carcinoma and Its Clinicopathological Significance. Proteomics2007     Jan ; 7(1) : 155-167 (SCI; IF:4.815, 13/71=18.3%)

  47. Pei-Ju Tai, Ya-Hui Huang (equal contribution), Chung-Hsuan Shih, Ruey-Nan Chen, Chi-De Chen, Wei-Jan Chen, Chia-Siu Wang, *K-H Lin Direct regulation of ARA70 by thyroid hormone and its receptors. Endocrinology 2007 148: 3485-3495 (SCI; IF:4.993, 20/116=17.2%)

  48. Ruey-Nan Chen, Ya-Hui Huang, Chau-Ting Yeh, Chen-Hsin Liao, *K-H Lin Thyroid hormone receptors suppress pituitary tumor transforming gene 1 activity in hepatoma. Cancer Res2008 68(6):1697-1706 (SCI; IF:8.234, 12/184=6.5%)

  49. Ruey-Nan Chen, Ya-Hui Huang, Ya-Chu Lin, Chau-Ting Yeh, Ying Liang, Shen-Liang Chen, *K-H Lin Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines. Endocrinology 2008 149(8):3817-3831 (SCI; IF:4.993, 20/116=17.2%)

  50. Ya-Hui Huang, Ming-ming Tsai, *K-H Lin Thyroid Hormone Dependent Regulation of Target Genes and Its Physiological Significance Chang Gung Medical J. 2008 31:325-334

  51. Wan-Li Cheng, Chia-Siu Wang, Ya-Hui Huang, Ying Liang, Paul Y. Lin, Chuen Hsueh, Yi-Chin Wu, Wei-Jan Chen, Chia-Jung Yu, Sheue-Rong Lin, *K-H Lin Overexpression of a secretory leukocyte protease inhibitor in human gastric cancer. Int. J Cancer 2008 123:1787–1796 (SCI; IF:4.926, 32/184=17.4%)

  52. W-J Chen, J-H Pang, K-H Lin and S-H Yang Propylthiouracil, independent of its antithyroid effect, decreases VSMC collagen expression Basic Research in Cardiology 2009 104:60-68(SCI; IF:6.128, 8/114=7%)

  53. C-S Liao, P-J Tai, Y-H Huang, R-N Chen, S-M Wu, L-W Kuo, C-T Yeh, M-M Tsai, W-J Chen, *K-H Lin Regulation of AKR1B1 by thyroid hormone and its receptors Mol. Cell. Endo.2009 June ; 307:109-117 (SCI; IF:4.119, 33/116=28.4%)

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